Jason J. Corneveaux

Molecular Biotechnology

Growing up in the rugged mountains of Utah, Mr. Corneveaux learned to appreciate and wonder at the endless beauty of nature through countless backcountry excursions with his father. Mr. Corneveaux originally came to ASU to pursue a degree in computer systems engineering, but his studies were cut short when family needs called him away. In his time away from ASU, Mr. Corneveaux witnessed the state of Arizona take bold strides to become a top player in the biotech industry, and believed that the state's ambitious goals were of vital importance. As such, he decided to change his major to molecular biotechnology and return to ASU in order to play a role in this exciting future.

In the summer of 2005, right before returning to ASU, Mr. Corneveaux was accepted into a prestigious internship program at the Translational Genomics Research Institute (TGen) in Phoenix. During his first few months he worked primarily on a project aimed at ultra-high resolution identification and characterization chromosomal copy number changes, from which he was awarded best poster presentation at the concluding Intern Symposium. Mr. Corneveaux also worked on several other projects including developing a genotype calling algorithm and a study that identified two genes highly implicated in human episodic memory function. Jason is an author on two manuscripts detailing these findings—one has recently been accepted to the journal Science and the other is under review by the journal Nature.

After completion of his summer internship, Mr. Corneveaux was hired as a research associate with Dr. Dietrich Stephan's Neurogenomics lab at TGen. In 2006, Mr. Corneveaux was awarded a scholarship by the Biostatistics Department at the University of Washington to attend the 2006 Summer Institute in Statistical Genetics. He was also named one of three Affymetrix Scholars for his exemplary work at TGen. In addition, Arizona State University awarded him an undergraduate research fellowship in the School of Life Science's esteemed SOLUR program for the '06-'07 school year. He is currently working closely with his mentor Dr. Matthew Huentelman on research aimed at identifying the genetic factors implicated in devastating neurological disorders including Alzheimer's Disease, autism, Parkinson's Disease, and more. The overall goals of Mr. Corneveaux's research are to identify and characterize genetic variation in order to quickly diagnose, treat, and soon cure neurological diseases. After graduating with his B.S., Mr. Corneveaux will pursue a PhD in neuroscience and biotechnology.

SELECTED PEER-REVIEWED PUBLICATIONS:

1. Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh K-D, Brunner F, Corneveaux JJ, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hanggi J, Mondadori CRA, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ-F. Common KIBRA alleles are associated with human memory performance in humans. Science (in press; accepted Sept 20, 2006).

2. Corneveaux JJ, Kruer MC, Hu-Lince D, Ramsey KE, Zismann VL, Stephan DA, Craig DW, Huentelman MJ. SNP-based chromosomal copy number ascertainment following multiple displacement whole-genome amplification. Biotechniques. (in press; accepted Sept 21, 2006).

3. Hentelman MJ, Craig DW, Shieh AD, Corneveaux JJ, Hu-Lince D, Pearson JV, Stephan DA. SNiPer: Improved SNP genotype calling for Affymetrix 10K GeneChip microarray data. BMC Genomics. 2005 Oct 31;6:149.

4. Kerrigan JF, Craig DW, Kruer MC, Corneveaux JJ, Panganiban CB, Itty A, Reiman D, Ng YT, Stephan DA. Chromosomal Abnormality at 6p25.1-25.3 Identifies A Susceptibility Locus For Hypothalamic Hamartoma Associated With Epilepsy. Epilepsia (submitted).

TRIPLE HELIX JOURNAL REVIEW ARTICLES:

1. Astronomers see the Big Bang in action. The Triple Helix. April 2006.

ABSTRACTS AND PRESENTATIONS:

1. Corneveaux JJ, Huentelman MJ, Craig DW, Lee AM, Stephan DA. Identification of chromosomal copy number abnormalities using microarrays. Summer Internship Symposia, Translational Genomics Research Institute. August 2005, Phoenix AZ.

2. Corneveaux JJ, Huentelman MJ, Craig DW, Lee AM, Stephan DA. Identifying chromosomal copy number polymorphisms in humans assayed with 100k & 500k SNP arrays. 1st Annual Arizona State University CLAS Undergraduate Research Symposium. March 2006, Tempe, AZ.

3. Corneveaux JJ. Ultra-high density screening of human chromosomal copy number polymorphisms with 100k & 500k SNP arrays.

Arizona State University Associate Students of Biotechnology. April 2006, Tempe, AZ.

4. Corneveaux JJ, Huentelman MJ, Craig DW, Coon KD, Zismann VL, Webster JA, Lee AM, Stephan DA. Ultra-high density screening of human chromosomal copy number polymorphisms with 100k & 500k SNP arrays. Annual Translational Genomics Research Institute Scientific Retreat. May 2006, Phoenix AZ.